Maddrey Discriminant Function Calculator
Enter the prothrombin time, control PT and bilirubin to get the Maddrey discriminant function.
Result
How to use
- Enter your values in the fields above.
- Press Calculate to see your result instantly.
- Use the Share button to copy a link to your result.
About this calculator
The Maddrey discriminant function (DF) is a validated clinical score for assessing the severity of alcoholic hepatitis, calculated as 4.6 × (patient's prothrombin time − control PT, in seconds) + serum bilirubin (mg/dL). It combines a measure of liver synthetic function (PT) with a measure of cholestasis and hepatocyte injury (bilirubin).
A DF of 32 or higher defines severe alcoholic hepatitis and is the threshold clinicians use to consider corticosteroid therapy, since patients above this cutoff face significantly higher short-term mortality without treatment. Hepatologists use it alongside newer scores like MELD to guide steroid decisions.
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